Upper Midwest Islet Club Conference - April 30 to May 2, 2008 with logo

Scientific and Social Program of the 1st UMIC Meeting

Wednesday, April 30, 2008
6:00 PM Dinner
7:30 PM Welcoming Ceremony:

Dr. Donald Steiner from the University of Chicago will present the Lacy Medal Lecture (Introduction by Dr. Alan Permutt)
   
Thursday, May 1, 2008
7:00 - 7:55 AM Breakfast
8:00 - 8:10 AM Welcome and Introduction: Roland Stein (host)/ Chris Rhodes
8:10 - 9:45 AM Islet Development (Moderator: Roland Stein)
8:10 – 8:25 am FONG CHENG PAN – ‘Determination of lineage potency/restriction of Ptf1a-expressing cells during pancreas development’
8:25 – 8:40 am ROBERT VINCENT – ‘Recapitulating pancreas development in embryonic stem cells with controlled expression of PTF1a’
8.40 – 8.55 am GOKAN DALGIN – ‘Zebrafish Hoxb1 and Hoxb5 group genes regulate early patterning of endocrine pancreas’
8.55 – 9.10 am C. CRAS MENEUR – ‘Notch/Presenilin signaling is critical for correct endocrine fate in Ngn3-expressing islet progenitor cells’
9.10 – 9.25 am SUI WANG – ‘Myt1 and Ngn3 from a feed forward expression loop to regulate endocrine differentiation’
9.25 – 9.40 am LEAH POTTER – ‘Nonequivalency of activin and nodal on the endoderm gene signature of human ES cells’

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9:45 - 10:30 AM Coffee
10:30 - 12:30 PM Pancreatic Islet Genes And Gene Regulation (Moderator: Alan Permutt)
10:30 – 10:45 am JENNIFER PLANK – ‘Investigating the role of Foxd3 in the pancreas’
10:45 – 11:00 am JEFFREY RAUM – ‘MafA sequences spanning the conserved Region-3 drive islet beta-cell-specific transcription’
11:00 – 11.15 am YINGDA WANG – ‘Long-Range Enhancers are Required to Maintain Expression of the Autoantigen IGRP in Adult Mouse Islets’
11.15 – 11.30 am TYE DEERING – ‘The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes’
11.30 – 11.45 am TAKESHI OGIHARA – ‘Liver X receptor agonism augments glucose-stimulated insulin transcription and secretion in human islets’
11.45 – 12.00 am SHIN TSNUEKAWA – ‘Glucose regulation of IRS-2 promoter activity in pancreatic beta cells’
12.00 – 12.15 am SHUANGLI GOU – ‘MafA activity is regulated by phosphorylation’
12:15 - 1:30 AM Lunch
1:30 - 3:30 PM Pancreatic ฿-Cell Growth and Regeneration (Moderator: Andy Stewart)

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1:30 – 1.45 pm LAURA ALONSO – ‘Protein kinase C (PKC) z (zeta) activation is essential for glucose-mediated ฿-cell proliferation’
1.45 – 2.00 pm NATHALIE FLASCHI-TAESCH – ‘Overexpression of cdk6, A Human Specific beta Cell Cdk, Induces Human beta Cell Proliferation and Promotes Engraftment and Function of Human Islets’
2.00 – 2.15 pm JEREMY LAVINE – ‘Overexpression of cholecystokinin in isolated human islets stimulates beta-cell proliferation’
2.15 – 2.30 pm NORMAN BALCAZAR – ‘Disruption of Tsc2 in pancreatic beta-cells induces ฿cell mass expansion and improved glucose’
2.30 – 2.45 pm ALEXANDER STOECK – ‘Sequential Processing of betacellulin in pancreatic epithelial and beta-cells: implications for ErbB receptor independent signaling’
2.45 – 3.00 pm AMANDA ACKERMANN – ‘Beta Cell Proliferation and Regeneration Following 60% Partial Pancreatectomy are Impaired in the Absence of FoxM1’
3.00 – 3.15 pm CHANG-ZHENG WANG – ‘MIP-hDTR-GFP transgenic mice: A new model for studying beta-cell regeneration’

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3.15 - 4.00pm Coffee
4.00 - 6.00 pm Islet function and insulin secretion (Moderator: Chris Rhodes)
4:00 – 4.15 pm SIRI ATMA GREELEY – ‘Mutations in the Insulin Gene are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood’
4.15 – 4.30 pm RACHEL REINERT – ‘Normal Pancreatic Islet Innervation Requires Vascular Endothelial Growth Factor-A (VEGF-A)’
4.30 – 4.45 pm JOHN DISHINGER – ‘Measuring Single Islet Insulin Secretion in Parallel on a Microscale Device: Using Microfluidics to Study the Effects of the Leptin Signaling Pathway on Insulin Secretion’
4.45 – 5.00 pm CHRISTOPHER EASLEY – ‘Quantitative measurement of zinc and insulin secretions from single pancreatic islets with high temporal resolution’
5.00 – 5.15 pm STEFANI EAMES – ‘Genetically Targeted Calcium Indicator Facilitates Functional Imaging of Beta-cells in Live Zebrafish’
5.15 – 5.30 pm RICHARD BENNINGER – ‘Gap junction communication in the pancreatic islet’
5.30 – 5.45 pm JAMES LOPEZ – ‘Glucose Regulation of Cortical Actin through ERM Proteins in Pancreatic Beta Cells’

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6.15 - 8.00 pm Conference Banquet
8.00 - 10.00 pm WPoster Session/Bar
Friday, May 2, 2008
7.00 – 7.55 am Breakfast
8.00 - 10.00 am Beta-cell Death (Moderator: Peter Arvan)
8.00 – 8.15 am WIEKE FREUDENBURG DE GRAAF – ‘Role of Type I Interferons in the Induction of Immunoproteasomes in Beta-Cells’
8.15 – 8.30 am XIAOYONG LEI – ‘Ceramides and their role in ER stress-induced beta-cell death: Implications for T1DM’
8.30 – 8.45 am CHRIS GREEN – ‘Decreased Expression and Activity of Stearoyl-CoA Desaturase in Pancreatic Beta-Cells Increases the Susceptibility to Saturated Fatty Acid-Induced Apoptosis’
8.45 – 9.00 am MING LIU – ‘Proinsulin misfolding and pancreatic beta cell failure’
9.00 – 9.15 am BENBO SONG – ‘Genetic deletion of C/EBP homologous protein CHOP reduces oxidative stress, improves beta cell function’
9.15 – 9.30 am SAXENA GEETU – ‘TXNIP-induced Beta Cell Apoptosis follows the Mitochondrial Pathway’
9.30 – 9.45 am WENBO YAN – ‘B-EGF Deficient Mice Display Glucose Intolerance and Beta Cell Dysfunction’

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9.45am - 10.30 am Coffee
10.30 - 12.00 noon ฿-Cell Dysfunction, Diabetes and Therapies (Moderator: Alan Attie)
10.30 – 10.45 am KATSUYA TANABE – ‘Genetic Deficiency of Glycogen Synthase Kinase-3beta Corrects Diabetes in Mouse Models of Insulin Resistance’
10.45 – 11.00 am ANTHONY TRACE – ‘Identification of Eukaryotic Initiation Faactor 5A as a Novel Mediator of Cytokine-Induced Pancreatic Islet Dysfunction’
11.00 – 11.15 am JOSEPH KOSTER – ‘Mutation of residue G53 in Kir6.2 (KCNJ11) causing neonatal diabetes: A clinical and functional analysis’
11.15 – 11.30 am MARIA REMEDI – ‘Overactive ฿-cell KATP Channels Underlie Severe Diabetes with Secondary Complications in the Islet’
11.30 - 11.45 AM GAUTAM RAJPAL – ‘Expression and Bioactivity of Single Chain Insulins’
11.45 – 12.00 am EUNJIN OH – ‘Munc18c depletion selectively impairs sustained phase of insulin release’
12.00 - 12.15 PM Summing up, thanks and finale – Roland Stein (host)/Chris Rhodes
Meeting close, box lunch and departure.

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